Swine is one of the most biologically important large animal models in biomedical research. Swine also provide an attractive choice both for 3R principle and One Biomedical research because of their employment as a domestic animal that can be used as a free cell/ organ source for research and their high vulnerability to human diseases. The pig model’s arguably limited immunological toolkit has previously been one of its most restricting characteristics. This toolkit has dramatically improved in the previous decade, such as the ability to analyse swine T-cells. The swine paradigm for scientific research is summarised in this article, with an emphasis on T lymphocytes. It compares the pig model towards the more often used mouse and nonhuman monkey models before outlining the existing capabilities for characterising and expanding our knowledge of porcine T cells. Following that, it not only considers prior biomedical T-cell research, but also expands into areas where further in-depth T-cell studies could be extremely beneficial to biomedical research. While the former should provide information on swine biomedical T-cell research results, the latter should encourage swine T-cell researchers to collaborate with researchers in other fields such as nourishment, allergy, cancer, organ transplants, infectious illnesses, or vaccine development